The Evolution of Resistance to Cephalosporins
نویسندگان
چکیده
منابع مشابه
The evolution of resistance to cephalosporins.
The expression of resistance to cephalosporins is highly varied and due to various mechanisms. The greatest disadvantage of the cephalosporins is that they are inactivated by the array of beta-lactamases produced by bacteria. The high levels of chromosomal enzymes produced by these organisms are a major cause of cephalosporin resistance. Plasmid-mediated beta-lactamases (PMBLs) have also been i...
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When disks containing cefuroxime (CXM) or HR 756 (756) were placed next to cefoxitin (FOX) on plates inoculated with Enterobacter resistant to FOX, there was marked flattening of the zones of inhibition produced by CXM or 756, but colonies growing near the CXM or 756 disks were found to be fully susceptible to these drugs on retesting. In contrast, when a checkerboard titration with CXM or 756 ...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 1997
ISSN: 1058-4838,1537-6591
DOI: 10.1093/clinids/24.3.487